SCHEDULE 13G

Amendment No. 1 
CHIMERIX INC 
Common Stock 
Cusip #16934W106 


Cusip #16934W106 
Item 1:	Reporting Person - FMR LLC
Item 4:	Delaware
Item 5:	15,100 
Item 6:	0 
Item 7:	2,436,363 
Item 8:	0 
Item 9:	2,436,363 
Item 11:	9.222% 
Item 12:	    HC


Cusip #16934W106  
Item 1:	Reporting Person - Edward C. Johnson 3d 
Item 4:	United States of America
Item 5:	0 
Item 6:	0 
Item 7:	2,436,363 
Item 8:	0 
Item 9:	2,436,363 
Item 11:	9.222% 
Item 12:	IN 




	SCHEDULE 13G - TO BE INCLUDED IN 
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)



Item 1(a).	Name of Issuer:	

		CHIMERIX INC 

Item 1(b).	Name of Issuer's Principal Executive Offices:

		2505 MERIDIAN PKWY
		SUITE 340 
		DURHAM, NC  27713
		  

Item 2(a).	Name of Person Filing: 

		FMR LLC

Item 2(b).	Address or Principal Business Office or, if None, 
Residence:

		245 Summer Street, Boston, 
Massachusetts  02210

Item 2(c).	Citizenship:

		Not applicable

Item 2(d).	Title of Class of Securities:

		Common Stock 

Item 2(e).	CUSIP Number:  

		16934W106 

Item 3.	This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) 
and the person filing, FMR LLC, is a parent holding company 
in accordance with Section 240.13d-1(b)(ii)(G).  (Note:  See 
Item 7).

Item 4.	Ownership

	(a)	Amount Beneficially Owned:	2,436,363 

	(b)	Percent of Class:	9.222% 

	(c)	Number of shares as to which such 
person has:  

	(i)	sole power to vote or to direct 
the vote:	15,100 

	(ii)	shared power to vote or to 
direct the vote:	0 

	(iii)	sole power to dispose or to 
direct the disposition of:	2,436,363 

	(iv)	shared power to dispose or to 
direct the disposition of:	0 



Item 5.	Ownership of Five Percent or Less of a Class.

	Not applicable.

Item 6.	Ownership of More than Five Percent on Behalf of Another 
Person.

	Various persons have the right to receive or the power to 
direct the receipt of dividends from, or the proceeds from the 
sale of, the Common Stock of CHIMERIX INC.  The interest 
of one person, Fidelity Growth Company Fund, an investment 
company registered under the Investment Company Act of 
1940, in the Common Stock of CHIMERIX INC, amounted to 
1,751,700 shares or 6.630% of the total outstanding Common 
Stock at December 31, 2013. 

Item 7.	Identification and Classification of the Subsidiary Which 
Acquired the Security Being Reported on By the Parent 
Holding Company.

	See attached Exhibit A. 

Item 8.	Identification and Classification of Members of 
the Group.

	Not applicable.  See attached Exhibit A. 

Item 9.	Notice of Dissolution of Group.

	Not applicable.

Item 10.	Certification.  

	By signing below I certify that, to the best of my knowledge 
and belief, the securities referred to above were acquired in the 
ordinary course of business and were not acquired for the 
purpose of and do not have the effect of changing or 
influencing the control of the issuer of such securities and 
were not acquired in connection with or as a participant in any 
transaction having such purpose or effect.     

Signature

	After reasonable inquiry and to the best of my knowledge and 
belief, I certify that the information set forth in this statement 
is true, complete and correct. 

February 13, 2014 			
Date

 /s/ Scott C. Goebel			
Signature

Scott C. Goebel				
Duly authorized under Power of Attorney
effective as of June 1, 2008 by and on behalf of FMR LLC 
and its direct and indirect  subsidiaries


	SCHEDULE 13G - TO BE INCLUDED IN 
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)



	Pursuant to the instructions in Item 7 of Schedule 13G, 
Fidelity Management & Research Company ("Fidelity"), 245 
Summer Street, Boston, Massachusetts 02210, a wholly-
owned subsidiary of FMR LLC and an investment adviser 
registered under Section 203 of the Investment Advisers Act 
of 1940, is the beneficial owner of 2,267,800 shares or 8.584% 
of the Common Stock outstanding of CHIMERIX INC  ("the 
Company") as a result of acting as investment adviser to 
various investment companies registered under Section 8 of 
the Investment Company Act of 1940.

	Edward C. Johnson 3d and FMR LLC, through its 
control of Fidelity, and the funds each has sole power to 
dispose of the 2,267,800 shares owned by the Funds.

	Fidelity SelectCo, LLC ("SelectCo"), 1225 17th Street, 
Suite 1100, Denver, Colorado 80202, a wholly-owned 
subsidiary of FMR LLC and an investment adviser registered 
under Section 203 of the Investment Advisers Act of 1940, is 
the beneficial owner of 153,463 shares or 0.581% of the 
Common Stock outstanding of CHIMERIX INC ("the 
Company") as a result of acting as investment adviser to 
various investment companies registered under Section 8 of 
the Investment Company Act of 1940 (the "SelectCo Funds").

	Edward C. Johnson 3d and FMR LLC, through its 
control of SelectCo, and the SelectCo Funds each has sole 
power to dispose of the 153,463 owned by the SelectCo 
Funds.

	The ownership of one investment company, Fidelity 
Growth Company Fund, amounted to 1,751,700 shares or 
6.630% of the Common Stock outstanding. Fidelity Growth 
Company Fund has its principal business office at 245 
Summer Street, Boston, Massachusetts 02210.

	Members of the family of Edward C. Johnson 3d, 
Chairman of FMR LLC, are the predominant owners, directly 
or through trusts, of Series B voting common shares of FMR 
LLC, representing 49% of the voting power of FMR LLC.  
The Johnson family group and all other Series B shareholders 
have entered into a shareholders' voting agreement under 
which all Series B voting common shares will be voted in 
accordance with the majority vote of Series B voting common 
shares.  Accordingly, through their ownership of voting 
common shares and the execution of the shareholders' voting 
agreement, members of the Johnson family may be deemed, 
under the Investment Company Act of 1940, to form a 
controlling group with respect to FMR LLC.

	Neither FMR LLC nor Edward C. Johnson 3d, 
Chairman of FMR LLC, has the sole power to vote or direct 
the voting of the shares owned directly by the Fidelity Funds, 
which power resides with the Funds' Boards of Trustees.  
Fidelity carries out the voting of the shares under written 
guidelines established by the Funds' Boards of Trustees.

	Pyramis Global Advisors Trust Company ("PGATC"), 
900 Salem Street, Smithfield, Rhode Island, 02917, an indirect 
wholly-owned subsidiary of FMR LLC and a bank as defined 
in Section 3(a)(6) of the Securities Exchange Act of 1934, is 
the beneficial owner of 15,100 shares or 0.057% of the 
outstanding Common Stock of the CHIMERIX INC as a result 
of its serving as investment manager of institutional accounts 
owning such shares.

	Edward C. Johnson 3d and FMR LLC, through its 
control of Pyramis Global Advisors Trust Company, each has 
sole dispositive power over 15,100 shares and sole power to 
vote or to direct the voting of 15,100 shares of Common Stock 
owned by the institutional accounts managed by PGATC as 
reported above.



	SCHEDULE 13G - TO BE INCLUDED IN 
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)
	RULE 13d-1(f)(1)  AGREEMENT

	The undersigned persons, on February 13, 2014, agree 
and consent to the joint filing on their behalf of this Schedule 
13G in connection with their beneficial ownership of the 
Common Stock of CHIMERIX INC at December 31, 2013.

	FMR LLC

	By /s/ Scott C. Goebel			
	Scott C. Goebel
	Duly authorized under Power of Attorney effective as 
of June 1, 2008, by and on behalf of FMR LLC and its direct 
and indirect subsidiaries

	Edward C. Johnson 3d

	By /s/ Scott C. Goebel			
	Scott C. Goebel
	Duly authorized under Power of Attorney effective as 
of June 1, 2008, by and on behalf of Edward C. Johnson 3d

	Fidelity Management & Research Company

	By /s/ Scott C. Goebel			
	Scott C. Goebel
	Senior V.P. and General Counsel

	Fidelity Growth Company Fund

	By /s/ Scott C. Goebel			
	Scott C. Goebel
	Secretary