United States securities and exchange commission logo

                          August 13, 2020

       Michael A. Sherman
       Chief Executive Officer
       Chimerix, Inc.
       2505 Meridian Parkway, Suite 100
       Durham, NC 27713

                                                        Re: Chimerix, Inc.
Statement on Form S-3
                                                            Filed August 10,
                                                            File No. 333-244146

       Dear Mr. Sherman:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Ada D.
Sarmento at 202-551-3798 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Jason L. Kent, Esq.