United States securities and exchange commission logo August 13, 2020 Michael A. Sherman Chief Executive Officer Chimerix, Inc. 2505 Meridian Parkway, Suite 100 Durham, NC 27713 Re: Chimerix, Inc. Registration Statement on Form S-3 Filed August 10, 2020 File No. 333-244146 Dear Mr. Sherman: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Ada D. Sarmento at 202-551-3798 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Jason L. Kent, Esq.