United States securities and exchange commission logo

                          March 1, 2024

       Michael T. Andriole
       President and Chief Executive Officer
       Chimerix, Inc.
       2505 Meridian Parkway, Suite 100
       Durham, NC 27713

                                                        Re: Chimerix, Inc.
Statement on Form S-3
                                                            Filed February 29,
                                                            File No. 333-277505

       Dear Michael T. Andriole:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Chris
Edwards at 202-551-6761 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Jason L. Kent, Esq.