2101100 - Disclosure - The Business and Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 2401404 - Disclosure - The Business and Summary of Significant Accounting Policies (Assets and Liabilities Measured at Fair Value on a Recurring Basis) (Details) link:presentationLink link:calculationLink link:definitionLink 2401403 - Disclosure - The Business and Summary of Significant Accounting Policies (Narrative) (Details) link:presentationLink link:calculationLink link:definitionLink 2201201 - Disclosure - The Business and Summary of Significant Accounting Policies (Policy) link:presentationLink link:calculationLink link:definitionLink 2401405 - Disclosure - The Business and Summary of Significant Accounting Policies (Schedule of Accrued Liabilities) (Details) link:presentationLink link:calculationLink link:definitionLink 2301302 - Disclosure - The Business and Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 2104100 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 2404401 - Disclosure - Commitments and Contingencies (Narrative) (Details) link:presentationLink link:calculationLink link:definitionLink 1001000 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 1001501 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1003000 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1002000 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 0001000 - Document - Document And Entity Information link:presentationLink link:calculationLink link:definitionLink 2105100 - Disclosure - Equity Transactions and Share-based Compensation link:presentationLink link:calculationLink link:definitionLink 2405402 - Disclosure - Equity Transactions and Share-based Compensation - Common Stock Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2405403 - Disclosure - Equity Transactions and Share-based Compensation - Stock-based Compensation (Narrative) (Details) link:presentationLink link:calculationLink link:definitionLink 2405404 - Disclosure - Equity Transactions and Share-based Compensation - Stock-based Compensation (Schedule of Stock-based Compensation Expense) (Details) link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Equity Transactions and Share-based Compensation - Stock-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 2106100 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 2406401 - Disclosure - Income Taxes (Narrative) (Details) link:presentationLink link:calculationLink link:definitionLink 2102100 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 2402404 - Disclosure - Investments - Schedule of Investment Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 2402402 - Disclosure - Investments - Summary of Available-for-Sale securities (Details) link:presentationLink link:calculationLink link:definitionLink 2402403 - Disclosure - Investments - Summary of Investments with Unrealized Losses, Aggregated by Investment Type and the Length of Time (Details) link:presentationLink link:calculationLink link:definitionLink 2302301 - Disclosure - Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 2107100 - Disclosure - Significant Agreements link:presentationLink link:calculationLink link:definitionLink 2407401 - Disclosure - Significant Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2108100 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink